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ea0035p835 | Pituitary Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

AIP expression in non-functioning pituitary adenomas is strongly associated with the gonadotroph phenotype but not with tumour aggressiveness

Rotondi Sandra , Oliva Maria Antonietta , Esposito Vincenzo , Ventura Luca , Giangaspero Felice , Alesse Edoardo , Jaffrain-Rea Marielise

The aryl hydrocarbon receptor interacting protein gene has been mainly involved in the pathogenesis of GH/PRL-secreting pituitary adenomas (PA). We wished to study the significance of AIP expression in clinically non-functioning PA (NFPA).Material and methods: 48 NFPA -27 gonadotroph (GnPA), 21 null cell (ncPA) were studied for AIP, βFSH and cyclin D1 expression by real-time RT-PCR (qRT), compared with four normal post-mortem pituitaries (NP)...

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ea0035p834 | Pituitary Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Expression of peroxisome-proliferator activated receptor α in pituitary tumours

Rotondi Sandra , Modarelli Alessio , Rostomyan Lilya , Oliva Maria Antonietta , Esposito Vincenzo , Ventura Luca , Arcella Antonietta , Alesse Edoardo , Beckers Albert , Jaffrain-Rea Marielise

Peroxisome-proliferator activated receptors (PPARs) are involved in a number of neoplasia. PPARα (PPARα) is a partner of the aryl hydrocarbon receptor interacting protein (AIP), which is involved in the pathogenesis of pituitary adenomas (PA). We wished to investigate the potential expression and biological significance of PPARα in PA, especially in GH/PRL-secreting tumours.Material and methods: A large series of PA was collected (n</e...

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Endocrine Abstracts

AIP expression in non-functioning pituitary adenomas is strongly associated with the gonadotroph phenotype but not with tumour aggressiveness

Expression of peroxisome-proliferator activated receptor α in pituitary tumours

BiosciAbstracts